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4/1/2012 · The antiplasmodial activity of the isolated compounds was evaluated in vitro against the chloroquine-resistant Plasmodium falciparum strain W2. Results: Isolated compounds were identified as bacilosarcin A (1), AI77-F (2), and AI77-H (3).

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The antiplasmodial activity was determined in a chloroquine-resistant P. falciparum strain (W2) utilizing a microfluorimetric assay to measure the inhibition of the parasite growth based on the detection of the parasitic DNA by intercalation with PicoGreen. P. falciparum was cultured according to the methods described by Trager and Jensen. The